At a time of increasing disconnectedness from nature, scientific interest in the potential health benefits of connecting with nature has grown. Research in recent decades has yielded substantial evidence of nature’s health benefits, but large gaps still remain. The Center for Creative Conservation’s Nature and Health working group recently published a proposed research agenda on nature contact and health. Guided by a focus on key unanswered questions, new research has the potential to yield high-impact, consequential public health insights.